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Texas Department of Transportation reports a major crash on Highway 281, blocking multiple lanes of traffic in San Antonio. Read More

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The new Klein Smokehaus is at 604 Highway 281, Johnson City, TX 78636. The original store ... people from San Antonio, Bulverde, Spring Branch, Houston and the Dallas area," Klein said. Read More

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ALSO READ: Texas school district bans Bibles from ... The second most affordable ZIP code went to 78261 in far north central San Antonio, off Highway 281. The next three most affordable ZIP ... Read More

DONIPHAN, Neb. (KSNB) - Emergency personnel responded to a crash on Highway 281 in Doniphan Thursday evening. Around 7:50 p.m., a Nebraska 511 map showed slowed traffic near HWY 281 and Clarice Street ... Read More

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The intersection of U.S. Highway 281 South and 17th Street Southwest on top of Mill Hill will continue to be a four-way flashing stop beginning Wednesday, Jan. 8, according to the city engineer's ... Read More

Fire happened on Progress Road near U.S. Highway 281 in far south Bexar County on Dec. 28 Read full article: Ticket prices for Cotton Bowl Classic slashed as cold front sweeps through Texas Cold ... Read More

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HAMILTON COUNTY, Texas (KWTX) - The Hamilton County Sheriff's Office ... The vehicle was involved in a hit-and-run accident on Friday, Dec. 27, and was seen driving southbound on Highway 281, ... Read More